What does the corpus callosum tell us about brain changes in the elderly?
Expert Rev Neurother
; 11(11): 1557-60, 2011 Nov.
Article
in En
| MEDLINE
| ID: mdl-22014133
ABSTRACT
The corpus callosum is the largest hemispheric interconnection bundle in the human brain. Its anterior-posterior fiber caliber gradient can help in understanding the pathophysiological mechanisms underlying white matter changes both in old age and dementia. Here, the Leukoaraiosis and Disability (LADIS) study, a longitudinal cohort study, which shows an association between corpus callosum atrophy and cognitive and motor decline in the elderly, provides the possibility to consider the use of multimodal macro-microstructural imaging of corpus callosum as a marker of structural brain changes of physiological and pathological aging.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Observational_studies
/
Risk_factors_studies
Language:
En
Journal:
Expert Rev Neurother
Journal subject:
NEUROLOGIA
/
TERAPEUTICA
Year:
2011
Document type:
Article
Affiliation country:
Italy