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Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays.
Manfredi, Mark G; Ecsedy, Jeffrey A; Chakravarty, Arijit; Silverman, Lee; Zhang, Mengkun; Hoar, Kara M; Stroud, Stephen G; Chen, Wei; Shinde, Vaishali; Huck, Jessica J; Wysong, Deborah R; Janowick, David A; Hyer, Marc L; Leroy, Patrick J; Gershman, Rachel E; Silva, Matthew D; Germanos, Melissa S; Bolen, Joseph B; Claiborne, Christopher F; Sells, Todd B.
Affiliation
  • Manfredi MG; Millennium Pharmaceuticals, Inc., Cambridge, 40 Landsdowne Street, Cambridge, MA 02139, USA. mark.manfredi@mpi.com
Clin Cancer Res ; 17(24): 7614-24, 2011 Dec 15.
Article in En | MEDLINE | ID: mdl-22016509
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Azepines / Protein Serine-Threonine Kinases / Spindle Apparatus / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Azepines / Protein Serine-Threonine Kinases / Spindle Apparatus / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States