Sarcoid intermediate uveitis following etanercept treatment: a case report and review of the literature.
Ocul Immunol Inflamm
; 20(1): 44-8, 2012 Feb.
Article
in En
| MEDLINE
| ID: mdl-22017171
ABSTRACT
PURPOSE:
To describe a case of sarcoid uveitis subsequent to anti-TNFα therapy and review previously reported cases.METHODS:
Review of the clinical records of the authors' patient and of the literature using the PubMed database.RESULTS:
A 30-year-old woman presented with intermediate uveitis with snowballs in both eyes. She was on treatment with etanercept due to psoriatic arthritis. An ultrasound-guided biopsy of a mediastinal adenopathy showed non-necrotizing granulomas compatible with sarcoidosis. The clinical picture resolved after etanercept was withdrawn and treatment with immunosuppressants. In a literature search the authors identified six other cases of sarcoid uveitis induced by anti-TNFα therapy. The types of uveitis were anterior uveitis, posterior uveitis, or panuveitis. Management consisted of withdrawal of anti-TNFα therapy and administration of immunosuppressive agents in 5 cases.CONCLUSIONS:
Sarcoid uveitis induced by TNFα antagonists is a rare complication. Appropriate management consists of withdrawing the TNFα antagonist and giving immunosuppressants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcoidosis
/
Immunoglobulin G
/
Uveitis, Intermediate
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Ocul Immunol Inflamm
Journal subject:
ALERGIA E IMUNOLOGIA
/
OFTALMOLOGIA
Year:
2012
Document type:
Article