Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor.

Gårdsvoll, Henrik; Kjaergaard, Magnus; Jacobsen, Benedikte; Kriegbaum, Mette C; Huang, Mingdong; Ploug, Michael

Gårdsvoll, Henrik; Kjaergaard, Magnus; Jacobsen, Benedikte; Kriegbaum, Mette C; Huang, Mingdong; Ploug, Michael.

Affiliation

Gårdsvoll H; Finsen Laboratory, Rigshospitalet & Biotech Research and Innovation Centre, Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark.

J Biol Chem ; 286(50): 43515-26, 2011 Dec 16.

Article in En | MEDLINE | ID: mdl-22025616

Subject(s)

Pseudopodia/metabolism; Receptors, Urokinase Plasminogen Activator/chemistry; Receptors, Urokinase Plasminogen Activator/metabolism; Urokinase-Type Plasminogen Activator/metabolism; Animals; Cell Line; Chromatography, Gel; Circular Dichroism; Drosophila; Humans; Protein Structure, Secondary; Protein Structure, Tertiary; Somatomedins/chemistry; Somatomedins/metabolism; Surface Plasmon Resonance; Vitronectin/chemistry; Vitronectin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudopodia / Urokinase-Type Plasminogen Activator / Receptors, Urokinase Plasminogen Activator Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2011 Document type: Article Affiliation country: Denmark

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