Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy.

Zheng, Hongting; Whitman, Samantha A; Wu, Wei; Wondrak, Georg T; Wong, Pak K; Fang, Deyu; Zhang, Donna D

Zheng, Hongting; Whitman, Samantha A; Wu, Wei; Wondrak, Georg T; Wong, Pak K; Fang, Deyu; Zhang, Donna D.

Affiliation

Zheng H; Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA.

Diabetes ; 60(11): 3055-66, 2011 Nov.

Article in En | MEDLINE | ID: mdl-22025779

Subject(s)

Acrolein/analogs & derivatives; Diabetic Nephropathies/prevention & control; NF-E2-Related Factor 2/agonists; Thiocyanates/therapeutic use; Acrolein/administration & dosage; Acrolein/pharmacology; Acrolein/therapeutic use; Animals; Cell Proliferation/drug effects; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Diabetic Nephropathies/metabolism; Diabetic Nephropathies/pathology; Diabetic Nephropathies/physiopathology; Dose-Response Relationship, Drug; Extracellular Matrix Proteins/metabolism; Humans; Isothiocyanates; Kidney/drug effects; Kidney/pathology; Kidney/physiopathology; Mesangial Cells/drug effects; Mesangial Cells/metabolism; Mesangial Cells/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2/genetics; NF-E2-Related Factor 2/metabolism; Oxidative Stress/drug effects; RNA Interference; RNA, Small Interfering; Random Allocation; Reactive Oxygen Species/metabolism; Sulfoxides; Thiocyanates/administration & dosage; Thiocyanates/pharmacology; Transforming Growth Factor beta1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiocyanates / Acrolein / Diabetic Nephropathies / NF-E2-Related Factor 2 Type of study: Clinical_trials / Prognostic_studies Language: En Journal: Diabetes Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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