The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion.

Chin, A; Svejda, B; Gustafsson, B I; Granlund, A B; Sandvik, A K; Timberlake, A; Sumpio, B; Pfragner, R; Modlin, I M; Kidd, M

Chin, A; Svejda, B; Gustafsson, B I; Granlund, A B; Sandvik, A K; Timberlake, A; Sumpio, B; Pfragner, R; Modlin, I M; Kidd, M.

Affiliation

Chin A; Gastrointestinal Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.

Am J Physiol Gastrointest Liver Physiol ; 302(3): G397-405, 2012 Feb 01.

Article in En | MEDLINE | ID: mdl-22038827

Subject(s)

Adenosine/pharmacology; Enterochromaffin Cells/metabolism; Mechanotransduction, Cellular/physiology; Serotonin/metabolism; Signal Transduction/physiology; Acetamides/pharmacology; Adenosine A2 Receptor Agonists/pharmacology; Adenosine A2 Receptor Antagonists/pharmacology; Adenosine-5'-(N-ethylcarboxamide)/pharmacology; Adult; Aged; Cell Line, Tumor; Cells, Cultured; Colon/cytology; Crohn Disease/metabolism; Cyclic AMP/metabolism; Cyclic AMP Response Element-Binding Protein/metabolism; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases/metabolism; Enterochromaffin Cells/drug effects; Female; Gene Expression/genetics; Humans; MAP Kinase Kinase 1/antagonists & inhibitors; MAP Kinase Kinase 1/metabolism; MAP Kinase Signaling System/drug effects; MAP Kinase Signaling System/physiology; Male; Mechanotransduction, Cellular/drug effects; Middle Aged; Phosphorylation/drug effects; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/metabolism; Purines/pharmacology; Receptor, Adenosine A1/genetics; Receptor, Adenosine A2A/genetics; Receptor, Adenosine A2B/genetics; Receptor, Adenosine A2B/metabolism; Receptor, Adenosine A3/genetics; Signal Transduction/drug effects; Stress, Mechanical; Tryptophan Hydroxylase/genetics; Tryptophan Hydroxylase/metabolism; Vesicular Monoamine Transport Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Serotonin / Adenosine / Mechanotransduction, Cellular / Enterochromaffin Cells Type of study: Prognostic_studies Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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