Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory.
Science
; 334(6061): 1415-20, 2011 Dec 09.
Article
in En
| MEDLINE
| ID: mdl-22052975
ABSTRACT
Associating temporally discontinuous elements is crucial for the formation of episodic and working memories that depend on the hippocampal-entorhinal network. However, the neural circuits subserving these associations have remained unknown. The layer III inputs of the entorhinal cortex to the hippocampus may contribute to this process. To test this hypothesis, we generated a transgenic mouse in which these inputs are specifically inhibited. The mutant mice displayed significant impairments in spatial working-memory tasks and in the encoding phase of trace fear-conditioning. These results indicate a critical role of the entorhinal cortex layer III inputs to the hippocampus in temporal association memory.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Association Learning
/
Entorhinal Cortex
/
Conditioning, Psychological
/
Fear
/
Hippocampus
/
Memory, Short-Term
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Science
Year:
2011
Document type:
Article
Affiliation country:
United States