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5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
Stock, Nicholas S; Bain, Gretchen; Zunic, Jasmine; Li, Yiwei; Ziff, Jeannie; Roppe, Jeffrey; Santini, Angelina; Darlington, Janice; Prodanovich, Pat; King, Christopher D; Baccei, Christopher; Lee, Catherine; Rong, Haojing; Chapman, Charles; Broadhead, Alex; Lorrain, Dan; Correa, Lucia; Hutchinson, John H; Evans, Jilly F; Prasit, Peppi.
Affiliation
  • Stock NS; Department of Chemistry, Amira Pharmaceuticals, San Diego, California 92121, United States. nstock@inceptionsci.com
J Med Chem ; 54(23): 8013-29, 2011 Dec 08.
Article in En | MEDLINE | ID: mdl-22059882
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pentanoic Acids / Anti-Asthmatic Agents / 5-Lipoxygenase-Activating Protein Inhibitors / Indoles Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pentanoic Acids / Anti-Asthmatic Agents / 5-Lipoxygenase-Activating Protein Inhibitors / Indoles Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Document type: Article Affiliation country: United States