The oligo-acyl lysyl antimicrobial peptide C12K-2ß12 exhibits a dual mechanism of action and demonstrates strong in vivo efficacy against Helicobacter pylori.

Makobongo, Morris O; Gancz, Hanan; Carpenter, Beth M; McDaniel, Dennis P; Merrell, D Scott

Makobongo, Morris O; Gancz, Hanan; Carpenter, Beth M; McDaniel, Dennis P; Merrell, D Scott.

Affiliation

Makobongo MO; Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

Antimicrob Agents Chemother ; 56(1): 378-90, 2012 Jan.

Article in En | MEDLINE | ID: mdl-22064541

Subject(s)

Anti-Bacterial Agents/administration & dosage; Antimicrobial Cationic Peptides/administration & dosage; Cell Membrane Permeability/drug effects; Helicobacter Infections/drug therapy; Helicobacter pylori/drug effects; Peptidomimetics/administration & dosage; 1-Naphthylamine/analogs & derivatives; Administration, Oral; Animals; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/metabolism; Antimicrobial Cationic Peptides/chemical synthesis; Antimicrobial Cationic Peptides/metabolism; Blotting, Western; DNA, Bacterial/metabolism; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Fluorescent Dyes; Gerbillinae; Helicobacter Infections/microbiology; Helicobacter pylori/growth & development; Helicobacter pylori/ultrastructure; Microbial Sensitivity Tests; Microscopy, Electron; Peptidomimetics/chemical synthesis; Peptidomimetics/metabolism; Protein Binding; RNA, Bacterial/metabolism; Stomach/drug effects; Stomach/microbiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Membrane Permeability / Helicobacter pylori / Helicobacter Infections / Antimicrobial Cationic Peptides / Peptidomimetics / Anti-Bacterial Agents Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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