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Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.
Campbell, Dean O; Yaghoubi, Shahriar S; Su, Ying; Lee, Jason T; Auerbach, Martin S; Herschman, Harvey; Satyamurthy, Nagichettiar; Czernin, Johannes; Lavie, Arnon; Radu, Caius G.
Affiliation
  • Campbell DO; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, 90095; Ahmanson Translational Imaging Division, UCLA, Los Angeles, California, 90095.
  • Yaghoubi SS; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, 90095; Ahmanson Translational Imaging Division, UCLA, Los Angeles, California, 90095; CellSight Technologies, San Francisco, California 94107.
  • Su Y; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607.
  • Lee JT; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, 90095; Ahmanson Translational Imaging Division, UCLA, Los Angeles, California, 90095.
  • Auerbach MS; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, 90095; Ahmanson Translational Imaging Division, UCLA, Los Angeles, California, 90095.
  • Herschman H; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, 90095; Department of Biological Chemistry, UCLA, Los Angeles, California 90095.
  • Satyamurthy N; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, 90095; Ahmanson Translational Imaging Division, UCLA, Los Angeles, California, 90095.
  • Czernin J; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, 90095; Ahmanson Translational Imaging Division, UCLA, Los Angeles, California, 90095.
  • Lavie A; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607. Electronic address: Lavie@uic.edu.
  • Radu CG; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California, 90095; Ahmanson Translational Imaging Division, UCLA, Los Angeles, California, 90095. Electronic address: CRadu@mednet.ucla.edu.
J Biol Chem ; 287(1): 446-454, 2012 Jan 02.
Article in En | MEDLINE | ID: mdl-22074768
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymidine / Thymidine Kinase / Protein Engineering / Genes, Reporter / Positron-Emission Tomography Type of study: Prognostic_studies Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Biol Chem Year: 2012 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymidine / Thymidine Kinase / Protein Engineering / Genes, Reporter / Positron-Emission Tomography Type of study: Prognostic_studies Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Biol Chem Year: 2012 Document type: Article Country of publication: United States