Bacterial Proteins/chemistry; Bacterial Proteins/toxicity; Bacterial Toxins/chemistry; Bacterial Toxins/toxicity; Burkholderia pseudomallei/chemistry; Burkholderia pseudomallei/pathogenicity; Eukaryotic Initiation Factor-4A/antagonists & inhibitors; Amino Acid Motifs; Animals; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Bacterial Toxins/genetics; Bacterial Toxins/metabolism; Catalytic Domain; Cell Line; Crystallography, X-Ray; Cytotoxins/chemistry; Cytotoxins/genetics; Cytotoxins/metabolism; Cytotoxins/toxicity; Escherichia coli Proteins/chemistry; Eukaryotic Initiation Factor-4A/metabolism; Glutamine/metabolism; Humans; Mice; Mice, Inbred BALB C; Models, Molecular; Mutant Proteins/toxicity; Peptide Chain Initiation, Translational/drug effects; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary