Design, synthesis and cytotoxicity of novel chalcone analogs derived from 1-cyclohexylpyrrolidin-2-one and 2,3-dihydrobenzo[f]chromen-1-one.

Brien, Kimberly A; Bandi, Ravi Kumar; Behera, Ajaya Kumar; Mishra, Bijay Kumar; Majumdar, Poulomi; Satam, Vijay; Savagian, Mia; Tzou, Samuel; Lee, Megan; Zeller, Matthias; Robles, Andrew J; Mooberry, Susan; Pati, Hari; Lee, Moses

Brien, Kimberly A; Bandi, Ravi Kumar; Behera, Ajaya Kumar; Mishra, Bijay Kumar; Majumdar, Poulomi; Satam, Vijay; Savagian, Mia; Tzou, Samuel; Lee, Megan; Zeller, Matthias; Robles, Andrew J; Mooberry, Susan; Pati, Hari; Lee, Moses.

Affiliation

Brien KA; Division of Natural Sciences and Department of Chemistry, Hope College, Holland, MI, USA.

Arch Pharm (Weinheim) ; 345(5): 341-8, 2012 May.

Article in En | MEDLINE | ID: mdl-22076705

Subject(s)

Antineoplastic Agents/chemical synthesis; Chalcones/chemical synthesis; Chromones/chemistry; Cyclohexanes/chemistry; Pyrrolidinones/chemistry; Animals; Antineoplastic Agents/pharmacology; Cell Line, Tumor; Cell Survival/drug effects; Chalcones/chemistry; Chalcones/pharmacology; Drug Design; Humans; Mice; Structure-Activity Relationship; X-Ray Diffraction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidinones / Chromones / Cyclohexanes / Chalcones / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Arch Pharm (Weinheim) Year: 2012 Document type: Article Affiliation country: United States Country of publication: Germany

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