The pleiohomeotic functions as a negative regulator of Drosophila even-skipped gene during embryogenesis.
Mol Cells
; 32(6): 549-54, 2011 Dec.
Article
in En
| MEDLINE
| ID: mdl-22080372
ABSTRACT
Polycomb group (PcG) proteins maintain the spatial expression patterns of genes that are involved in cell-fate specification along the anterior-posterior (A/P) axis. This repression requires cis-acting silencers, which are called PcG response elements (PREs). One of the PcG proteins, Pleiohomeotic (Pho), which has a zinc finger DNA binding protein, plays a critical role in recruiting other PcG proteins to bind to PREs. In this study, we characterized the effects of a pho mutation on embryonic segmentation. pho maternal mutant embryos showed various segmental defects including pair-rule gene mutant patterns. Our results indicated that engrailed and even-skipped genes were misexpressed in pho mutant embryos, which caused embryonic segment defects.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Homeodomain Proteins
/
Drosophila Proteins
/
Embryonic Development
/
DNA-Binding Proteins
/
Drosophila melanogaster
Limits:
Animals
Language:
En
Journal:
Mol Cells
Journal subject:
BIOLOGIA MOLECULAR
Year:
2011
Document type:
Article