Tolerance to experimental contact sensitivity induced by T cell vaccination.
Eur J Immunol
; 20(9): 2083-7, 1990 Sep.
Article
in En
| MEDLINE
| ID: mdl-2209704
ABSTRACT
It was shown previously that experimental autoimmune diseases could be prevented or treated specifically by administering suitably attenuated autoimmune T lymphocytes to animals, a process termed T cell vaccination (Cohen, I. R., Sci. American 1988. 256 52). We now report that T cell vaccination is an effective way of inducing tolerance to contact sensitivity to simple chemical haptens. Vaccines were prepared from populations of lymph node cells from specifically sensitized mice by activating the T cells with the T cell mitogen concanavalin A and then treating the T cell blasts with glutaraldehyde. The vaccinated mice showed decreased delayed sensitivity responses to the specific sensitizing antigen and developed significant delayed sensitivity responses to the T cells of the same specificity as those used for vaccination. Thus, T cell vaccination against contact sensitivity reactions appears to function similarly to T cell vaccination against autoimmune disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
T-Lymphocytes
/
Immunotherapy, Adoptive
/
Vaccination
/
Dermatitis, Contact
/
Immune Tolerance
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Eur J Immunol
Year:
1990
Document type:
Article
Affiliation country:
Israel