Parkinsonian signs and symptoms in adults with a history of Sydenham's chorea.
Parkinsonism Relat Disord
; 18(5): 595-7, 2012 Jun.
Article
in En
| MEDLINE
| ID: mdl-22104009
ABSTRACT
BACKGROUND:
Sydenham's chorea is associated with dysfunction of fronto-striatal circuits induced by cross-reactive antibodies to group A ß-hemolytic streptococcus. High susceptibility of extrapyramidal effects of neuroleptics in patients with Sydenham's chorea suggests underlying nigro-striatal dysfunction.OBJECTIVE:
To study the presence of parkinsonism in patients with a history of Sydenham's Chorea.METHODS:
We used the UFMG Sydenham's Chorea Rating Scale (USCRS) and the Unified Parkinson's Disease Rating Scale (UPDRS) part III, respectively, to determine the presence of chorea and parkinsonian symptoms and signs in 25 adults with a history of previous Sydenham's Chorea currently without chorea or use of anti-choreic drugs.RESULTS:
Bradykinesia was found in 64% of subjects. There was a statistically significant correlation between bradykinesia and hemichorea (-0.412; p = 0.036) and bradykinesia and generalized chorea (0.412; p = 0.036). There was no correlation between bradykinesia and use of anti-choreic drugs.CONCLUSIONS:
Bradykinesia is common in patients with Sydenham's Chorea in remission. This finding suggests an immune-mediated dysfunction of the nigro-striatal system.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chorea
/
Hypokinesia
/
Parkinsonian Disorders
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Parkinsonism Relat Disord
Journal subject:
NEUROLOGIA
Year:
2012
Document type:
Article
Affiliation country:
Brazil