Lead diversification. Application to existing drug molecules: mifepristone 1 and antalarmin 8.

Abid Masood, M; Farrant, Elizabeth; Morao, Inaki; Bazin, Marc; Perez, Manuel; Bunnage, Mark E; Fancy, Sally-Ann; Peakman, Torren

Abid Masood, M; Farrant, Elizabeth; Morao, Inaki; Bazin, Marc; Perez, Manuel; Bunnage, Mark E; Fancy, Sally-Ann; Peakman, Torren.

Affiliation

Abid Masood M; Worldwide Medicinal Chemistry, Pfizer Worldwide R&D, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. mabidmasood@gmail.com

Bioorg Med Chem Lett ; 22(1): 723-8, 2012 Jan 01.

Article in En | MEDLINE | ID: mdl-22104142

Subject(s)

Chemistry, Pharmaceutical/methods; Mifepristone/pharmacology; Pyrimidines/pharmacology; Pyrroles/pharmacology; Biomimetics; Carbon/chemistry; Chlorine/chemistry; Drug Design; Humans; Hydrogen/chemistry; Inhibitory Concentration 50; Metalloporphyrins/chemistry; Metals/chemistry; Microsomes, Liver/drug effects; Models, Chemical; Oxygen/chemistry; Structure-Activity Relationship

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Pyrroles / Mifepristone / Chemistry, Pharmaceutical Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google