Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance.

van Oosterwijk, J G; Herpers, B; Meijer, D; Briaire-de Bruijn, I H; Cleton-Jansen, A M; Gelderblom, H; van de Water, B; Bovée, J V M G

van Oosterwijk, J G; Herpers, B; Meijer, D; Briaire-de Bruijn, I H; Cleton-Jansen, A M; Gelderblom, H; van de Water, B; Bovée, J V M G.

Affiliation

van Oosterwijk JG; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Ann Oncol ; 23(6): 1617-26, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22112972

Subject(s)

Antineoplastic Agents/pharmacology; Cisplatin/pharmacology; Doxorubicin/pharmacology; Proto-Oncogene Proteins c-bcl-2/metabolism; bcl-X Protein/metabolism; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters/metabolism; Antineoplastic Agents/metabolism; Apoptosis/drug effects; Biphenyl Compounds/pharmacology; Cell Culture Techniques; Cell Nucleus/metabolism; Cell Proliferation/drug effects; Cell Shape/drug effects; Cell Survival/drug effects; Chondrosarcoma; Dose-Response Relationship, Drug; Doxorubicin/metabolism; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression; HL-60 Cells; Humans; Inhibitory Concentration 50; Multidrug Resistance-Associated Proteins/metabolism; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins/metabolism; Nitrophenols/pharmacology; Piperazines/pharmacology; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors; Proto-Oncogene Proteins c-bcl-2/genetics; Sulfonamides/pharmacology; bcl-X Protein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / Cisplatin / Proto-Oncogene Proteins c-bcl-2 / Bcl-X Protein / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Ann Oncol Journal subject: NEOPLASIAS Year: 2012 Document type: Article Affiliation country: Netherlands

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