Amyloid-ß contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy.

Hartz, Anika M S; Bauer, Björn; Soldner, Emma L B; Wolf, Andrea; Boy, Sandra; Backhaus, Roland; Mihaljevic, Ivan; Bogdahn, Ulrich; Klünemann, Hans H; Schuierer, Gerhard; Schlachetzki, Felix

Hartz, Anika M S; Bauer, Björn; Soldner, Emma L B; Wolf, Andrea; Boy, Sandra; Backhaus, Roland; Mihaljevic, Ivan; Bogdahn, Ulrich; Klünemann, Hans H; Schuierer, Gerhard; Schlachetzki, Felix.

Affiliation

Hartz AM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.

Stroke ; 43(2): 514-23, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22116809

Subject(s)

Amyloid beta-Peptides/physiology; Amyloid beta-Protein Precursor/genetics; Blood-Brain Barrier/pathology; Cerebral Amyloid Angiopathy/genetics; Cerebral Amyloid Angiopathy/pathology; Aged; Aged, 80 and over; Animals; Apolipoproteins E/genetics; Blotting, Western; Capillaries/pathology; Cell Membrane/pathology; Cell Membrane/physiology; Cerebral Hemorrhage/etiology; Cerebral Hemorrhage/pathology; Female; Fluorescent Dyes; Hemosiderosis/etiology; Humans; Magnetic Resonance Imaging; Male; Matrix Metalloproteinases/metabolism; Mice; Mice, Transgenic; Middle Aged; Patient Selection; Phenotype; Stroke/classification; Stroke/etiology; Tight Junctions/pathology; Tomography, X-Ray Computed; Xanthenes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Amyloid beta-Peptides / Cerebral Amyloid Angiopathy / Amyloid beta-Protein Precursor Type of study: Etiology_studies Limits: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Stroke Year: 2012 Document type: Article Affiliation country: United States

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