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Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors.
Fryer, Ryan M; Muthukumarana, Akalushi; Chen, Rong Rhonda; Smith, James D; Mazurek, Suzanne Nodop; Harrington, Kyle E; Dinallo, Roger M; Burke, Jennifer; DiCapua, Frank M; Guo, Xin; Kirrane, Thomas M; Snow, Roger J; Zhang, Yunlong; Soleymanzadeh, Fariba; Madwed, Jeffrey B; Kashem, Mohammed A; Kugler, Stanley Z; O'Neill, Margaret M; Harrison, Paul C; Reinhart, Glenn A; Boyer, Stephen J.
Affiliation
  • Fryer RM; Department of Cardiometabolic Disease Research, Boehringer-Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877-0368, USA. ryan.fryer@boehringer-ingelheim.com
J Pharmacol Exp Ther ; 340(3): 492-500, 2012 Mar.
Article in En | MEDLINE | ID: mdl-22128344
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Benzimidazoles / Blood Pressure / Receptors, Adrenergic, alpha-2 / Receptors, Adrenergic, alpha-1 / Ribosomal Protein S6 Kinases, 90-kDa / Protein Kinase Inhibitors Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Benzimidazoles / Blood Pressure / Receptors, Adrenergic, alpha-2 / Receptors, Adrenergic, alpha-1 / Ribosomal Protein S6 Kinases, 90-kDa / Protein Kinase Inhibitors Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States