Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system.

Bhandary, Yashodhar P; Shetty, Shwetha K; Marudamuthu, Amarnath S; Gyetko, Margaret R; Idell, Steven; Gharaee-Kermani, Mehrnaz; Shetty, Rashmi S; Starcher, Barry C; Shetty, Sreerama

Bhandary, Yashodhar P; Shetty, Shwetha K; Marudamuthu, Amarnath S; Gyetko, Margaret R; Idell, Steven; Gharaee-Kermani, Mehrnaz; Shetty, Rashmi S; Starcher, Barry C; Shetty, Sreerama.

Affiliation

Bhandary YP; Texas Lung Injury Institute, Department of Medicine, The University of Texas Health Science Center, Tyler, Texas 75708, USA.

Am J Physiol Lung Cell Mol Physiol ; 302(5): L463-73, 2012 Mar 01.

Article in En | MEDLINE | ID: mdl-22140072

Subject(s)

Acute Lung Injury/pathology; Apoptosis/drug effects; Caveolin 1/pharmacology; Gene Expression; Peptide Fragments/pharmacology; Pulmonary Alveoli/pathology; Pulmonary Fibrosis/pathology; Respiratory Mucosa/physiopathology; Acute Lung Injury/chemically induced; Acute Lung Injury/prevention & control; Animals; Bleomycin; Caveolin 1/therapeutic use; Cells, Cultured; Collagen/metabolism; Cytoprotection; Humans; Lung/metabolism; Lung/pathology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments/therapeutic use; Plasminogen Activator Inhibitor 1/genetics; Plasminogen Activator Inhibitor 1/metabolism; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases/metabolism; Pulmonary Alveoli/metabolism; Pulmonary Fibrosis/chemically induced; Pulmonary Fibrosis/prevention & control; Receptors, Urokinase Plasminogen Activator/genetics; Receptors, Urokinase Plasminogen Activator/metabolism; Respiratory Mucosa/drug effects; Respiratory Mucosa/metabolism; Tumor Suppressor Protein p53/metabolism; Urokinase-Type Plasminogen Activator/genetics; Urokinase-Type Plasminogen Activator/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Pulmonary Alveoli / Pulmonary Fibrosis / Gene Expression / Apoptosis / Respiratory Mucosa / Caveolin 1 / Acute Lung Injury Limits: Animals / Humans Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2012 Document type: Article Affiliation country: United States

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