Environmental Pollutants/toxicity; Genomics/methods; Animals; Humans; Proto-Oncogene Mas; Risk Assessment/methods

-omics; 2,3,7,8-tetrachlorodibenzo-p-dioxin; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); ADME; APAP; AhR; Biological pathway; Cross-species; DBP; DNA; DRE; EGBE; EPA; Environmental Protection Agency; HMGCS2; Human health risk assessment; IRIS; Integrated Risk Information System; JUN; LOAEL; MOA; MYC; Molecular network; N-acetyl-p-aminophenol; NOAEL; NRC; National Research Council; PID; PPARα; PXR; RNA; RfC; RfD; Selective constraints; Systems biology; TCDD; TD; TK; absorption, distribution, metabolism, and excretion; aryl hydrocarbon receptor; deoxyribonucleic acid; dibutyl phthalate; dioxin response element; ethylene glycol monobutyl ether; jun proto-oncogene; lowest-observed-adverse-effect-level; mode of action; myelocytomatosis oncogene; no-observed-adverse-effect-level; percent identity; peroxisome proliferator activated receptor alpha; pregnane X receptor; reference concentration; reference dose; ribonucleic acid; toxicodynamic; toxicokinetic