Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation.

Zhang, ZhenZhen; Qin, XiuHong; Tong, Nianting; Zhao, XinFeng; Gong, YuanYuan; Shi, Yuhua; Wu, XingWei

Zhang, ZhenZhen; Qin, XiuHong; Tong, Nianting; Zhao, XinFeng; Gong, YuanYuan; Shi, Yuhua; Wu, XingWei.

Affiliation

Zhang Z; Department of Ophthalmology, Shanghai Jiaotong University affiliated Shanghai First People's Hospital, Wujin Road 85, Shanghai 200080, China.

Exp Eye Res ; 94(1): 98-108, 2012 Jan.

Article in En | MEDLINE | ID: mdl-22143029

Subject(s)

Histone Deacetylase Inhibitors/pharmacology; Neuroprotective Agents/pharmacology; Reperfusion Injury/prevention & control; Retinal Diseases/prevention & control; Retinal Ganglion Cells/drug effects; Transcriptional Activation/drug effects; Valproic Acid/pharmacology; Acetylation; Animals; Apoptosis/drug effects; Apoptotic Protease-Activating Factor 1/metabolism; Axons/drug effects; Axons/metabolism; Axons/pathology; Caspase 3/metabolism; Cytochromes c/metabolism; HSP70 Heat-Shock Proteins/metabolism; Histone Deacetylases/metabolism; Histones/metabolism; In Situ Nick-End Labeling; Injections, Subcutaneous; Male; Rats; Rats, Wistar; Reperfusion Injury/metabolism; Reperfusion Injury/pathology; Retinal Diseases/metabolism; Retinal Diseases/pathology; Retinal Ganglion Cells/metabolism; Retinal Ganglion Cells/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Diseases / Retinal Ganglion Cells / Reperfusion Injury / Transcriptional Activation / Valproic Acid / Neuroprotective Agents / Histone Deacetylase Inhibitors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Exp Eye Res Year: 2012 Document type: Article Affiliation country: China Country of publication: United kingdom

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