[The effects of joint administration of 6% hydroxyethyl starch 130/0.4 and high-volume hemofiltration on patients with acute lung injury and acute kidney injury].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
; 23(12): 755-8, 2011 Dec.
Article
in Zh
| MEDLINE
| ID: mdl-22153015
ABSTRACT
OBJECTIVE:
To evaluate the effects of administration of 6% hydroxyethyl starch (6% HES 130/0.4, voluven) in combination with high volume hemofiltration (HVHF) in patients with ALI and AKI.METHODS:
One hundred and eight patients with acute lung injury (ALI) and acute kidney injury (AKI) were enrolled from Department of Intensive Care Unit (ICU) of the provincial Hospital Affiliated to Shandong University between August 2006 and May 2011. The patients were randomly divided into two groups A (n = 68) and B (n = 40) to receive voluven (i.v., for volume resuscitation) and voluven+HVHF for 72 hours. The arterial blood lactate concentration (Lac), high sensitivity C-reactive protein (hs-CRP) serum concentration, pulmonary function index alveolar-arterial oxygen pressure difference [P(A-a)DO2] and oxygenation index (OI), as well as kidney function index serum cystatin C (Cyst C) and serum creatinine clearance rate (CCr) were measured at the time of admission and 72 hours after the treatment for statistical analysis.RESULTS:
In comparison with group A, group B had significantly (all P < 0.01) lower mean value in the level of arterial Lac (mmol/L 1.7 ± 0.7 vs. 2.7 ± 1.5), serum hs-CRP (mg/L 35.8 ± 18.8 vs. 99.5 ± 20.4), P(A-a)DO2 (mm Hg, 1 mm Hg=0.133 kPa 115.5 ± 23.1 vs. 155.4 ± 27.4), Cyst C (mg/L 2.06 ± 1.12 vs. 3.95 ± 2.06) and significantly higher (both P < 0.01) mean value of OI (mm Hg 295.2 ± 38.8 vs. 239.5 ± 32.7) and CCr (ml/min 108.71 ± 31.33 vs. 90.21 ± 30.35) 72 hours after treatment. The mortality rate of group B was significantly lower than group A [10.00%(4/40) vs. 29.41%(20/68), P < 0.05] 7 days after the admission.CONCLUSION:
6% HES 130/0.4 in combination with HVHF could improve the lung and kidney function of the patients with ALI and AKI, prevent the development of multiple organ dysfunction syndrome (MODS), therefore improve the survival rate of these patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hemofiltration
/
Hydroxyethyl Starch Derivatives
/
Acute Lung Injury
/
Acute Kidney Injury
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
Journal subject:
MEDICINA DE EMERGENCIA
/
TERAPIA INTENSIVA
Year:
2011
Document type:
Article
Affiliation country:
China