Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics.

Smits, Rogier A; Lim, Herman D; van der Meer, Tiffany; Kuhne, Sebastiaan; Bessembinder, Karin; Zuiderveld, Obbe P; Wijtmans, Maikel; de Esch, Iwan J P; Leurs, Rob

Smits, Rogier A; Lim, Herman D; van der Meer, Tiffany; Kuhne, Sebastiaan; Bessembinder, Karin; Zuiderveld, Obbe P; Wijtmans, Maikel; de Esch, Iwan J P; Leurs, Rob.

Affiliation

Smits RA; Griffin Discoveries BV, Department of Medicinal Chemistry, Room P-246, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.

Bioorg Med Chem Lett ; 22(1): 461-7, 2012 Jan 01.

Article in En | MEDLINE | ID: mdl-22153663

Subject(s)

Histamine Antagonists/chemical synthesis; Receptors, G-Protein-Coupled/antagonists & inhibitors; Receptors, G-Protein-Coupled/chemistry; Receptors, Histamine/chemistry; Animals; Biological Availability; Chemistry, Pharmaceutical/methods; Drug Design; Histamine Antagonists/pharmacology; Humans; Hypersensitivity/drug therapy; Inhibitory Concentration 50; Kinetics; Ligands; Mice; Models, Chemical; Models, Molecular; Molecular Conformation; Rats; Receptors, Histamine H4; Structure-Activity Relationship; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Histamine / Receptors, G-Protein-Coupled / Histamine Antagonists Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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