Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia.

Posey, Karen L; Coustry, Francoise; Veerisetty, Alka C; Liu, Peiman; Alcorn, Joseph L; Hecht, Jacqueline T

Posey, Karen L; Coustry, Francoise; Veerisetty, Alka C; Liu, Peiman; Alcorn, Joseph L; Hecht, Jacqueline T.

Affiliation

Posey KL; Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA.

Am J Pathol ; 180(2): 727-37, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22154935

Subject(s)

Achondroplasia/physiopathology; Chondrocytes/metabolism; Extracellular Matrix Proteins/metabolism; Glycoproteins/metabolism; Growth Plate/pathology; Transcription Factor CHOP/physiology; Achondroplasia/embryology; Animals; Apoptosis; Apoptosis Regulatory Proteins/metabolism; Bone Development/physiology; Cartilage, Articular/embryology; Cartilage, Articular/growth & development; Cartilage, Articular/metabolism; Growth Plate/embryology; Growth Plate/growth & development; Hindlimb/embryology; Hindlimb/growth & development; Hindlimb/metabolism; Matrilin Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Tibia/embryology; Tibia/growth & development; Tibia/metabolism; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Achondroplasia / Glycoproteins / Extracellular Matrix Proteins / Chondrocytes / Transcription Factor CHOP / Growth Plate Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Pathol Year: 2012 Document type: Article Affiliation country: United States

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