Persistent expression of hepatitis C virus non-structural proteins leads to increased autophagy and mitochondrial injury in human hepatoma cells.

Chu, Victor C; Bhattacharya, Sayanti; Nomoto, Ann; Lin, Jiahui; Zaidi, Syed Kashif; Oberley, Terry D; Weinman, Steven A; Azhar, Salman; Huang, Ting-Ting

Chu, Victor C; Bhattacharya, Sayanti; Nomoto, Ann; Lin, Jiahui; Zaidi, Syed Kashif; Oberley, Terry D; Weinman, Steven A; Azhar, Salman; Huang, Ting-Ting.

Affiliation

Chu VC; Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, United States of America.

PLoS One ; 6(12): e28551, 2011.

Article in En | MEDLINE | ID: mdl-22164304

Subject(s)

Autophagy; Carcinoma, Hepatocellular/virology; Hepacivirus/metabolism; Liver Neoplasms/virology; Mitochondria/metabolism; Animals; Antibodies/chemistry; Antioxidants/metabolism; Carcinoma, Hepatocellular/metabolism; Cell Line; Cell Line, Tumor; Cyclin D1/metabolism; Genome; Humans; Immunohistochemistry/methods; Liver Neoplasms/metabolism; Mice; Mice, Transgenic; Oxidation-Reduction; Time Factors; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Hepacivirus / Carcinoma, Hepatocellular / Liver Neoplasms / Mitochondria Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Document type: Article Affiliation country: United States

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