Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection.
AJNR Am J Neuroradiol
; 33(4): 773-8, 2012 Apr.
Article
in En
| MEDLINE
| ID: mdl-22173762
ABSTRACT
BACKGROUND AND PURPOSE:
3D-FLAIR imaging 24 hours after intratympanic gadolinium injection (IT-method) or 4 hours after IV injection (IV-method) has been used to visualize the endolymphatic hydrops in Ménière disease. The purpose of this study was to compare the degree of perilymph enhancement with the 2 methods and the perilymph contrast-effect difference with the IV-method in both sides in patients with unilateral Ménière disease. MATERIALS ANDMETHODS:
Sixty-one patients with Ménière disease or sudden SNHL were included in this study. Thirty-nine patients who underwent the unilateral IT-method (Gd-DTPA was diluted 8-fold with saline) and 22 patients who underwent the IV-method (a double-dose of Gd-HP-DO3A; 0.4 mL/kg body weight [ie, 0.2 mmol/kg body weight]) at 3T were analyzed retrospectively. Regions of interest of the cochlear perilymph and the medulla oblongata were determined on each image, and the signal-intensity ratio between the 2 (CM ratio) was subsequently evaluated. The differences in the CM ratio between the 2 methods (Student t test) and the IV-method CM ratio between the affected and unaffected sides in patients with unilateral Ménière disease (paired t test) were evaluated.RESULTS:
The IT-method CM ratio (2.98 ± 1.15, n = 39) was higher than the IV-method CM ratio (1.61 ± 0.60, n = 44; P < .001). In patients with unilateral Ménière disease who underwent the IV-method (n = 9), the CM ratio of the affected side (1.86 ± 0.74) was higher than that of the unaffected side (1.29 ± 0.31, P < .05).CONCLUSIONS:
In general, the IT-method provides higher perilymph enhancement than the IV-method. In the patients with unilateral Ménière disease who underwent the IV-method, the affected side had a higher contrast effect.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Perilymph
/
Tympanic Membrane
/
Magnetic Resonance Imaging
/
Image Enhancement
/
Gadolinium DTPA
/
Meniere Disease
Type of study:
Diagnostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
AJNR Am J Neuroradiol
Year:
2012
Document type:
Article
Affiliation country:
Japan