Potent inhibitors of LpxC for the treatment of Gram-negative infections.
J Med Chem
; 55(2): 914-23, 2012 Jan 26.
Article
in En
| MEDLINE
| ID: mdl-22175825
ABSTRACT
In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenyl Ethers
/
Pseudomonas Infections
/
Sulfides
/
Sulfones
/
Biphenyl Compounds
/
Amidohydrolases
/
Hydroxamic Acids
/
Anti-Bacterial Agents
Limits:
Animals
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
2012
Document type:
Article
Affiliation country:
United States