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2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction.
Hwa, Jeong Seok; Jin, Yong Chun; Lee, Young Soo; Ko, Young Shin; Kim, Young Min; Shi, Lian Yu; Kim, Hye Jung; Lee, Jae Heun; Ngoc, Tran Minh; Bae, Ki Hwan; Kim, Yeong Shik; Chang, Ki Churl.
Affiliation
  • Hwa JS; Department of Urology, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
J Ethnopharmacol ; 139(2): 605-15, 2012 Jan 31.
Article in En | MEDLINE | ID: mdl-22179023
Subject(s)
Acrolein/analogs & derivatives; Cardiotonic Agents/pharmacology; Cinnamomum aromaticum; Heme Oxygenase (Decyclizing)/biosynthesis; Myocardial Infarction/prevention & control; Myocardial Reperfusion Injury/prevention & control; Myocardium/enzymology; Plant Extracts/pharmacology; Acrolein/isolation & purification; Acrolein/pharmacology; Animals; Anti-Inflammatory Agents/pharmacology; Antioxidants/pharmacology; Cardiotonic Agents/isolation & purification; Cinnamomum aromaticum/chemistry; Coculture Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors/pharmacology; HMGB1 Protein/metabolism; Heme Oxygenase (Decyclizing)/antagonists & inhibitors; Heme Oxygenase (Decyclizing)/genetics; Heme Oxygenase-1/biosynthesis; Hemodynamics/drug effects; Human Umbilical Vein Endothelial Cells/drug effects; Human Umbilical Vein Endothelial Cells/enzymology; Human Umbilical Vein Endothelial Cells/immunology; Humans; Male; Myocardial Infarction/enzymology; Myocardial Infarction/pathology; Myocardial Infarction/physiopathology; Myocardial Reperfusion Injury/enzymology; Myocardial Reperfusion Injury/pathology; Myocardial Reperfusion Injury/physiopathology; Myocardium/pathology; NF-kappa B/genetics; NF-kappa B/metabolism; Neutrophil Infiltration/drug effects; Oxidative Stress/drug effects; Plant Extracts/isolation & purification; Plants, Medicinal; RNA Interference; Rats; Rats, Sprague-Dawley; Superoxide Dismutase/metabolism; Time Factors; Transfection; Troponin I/metabolism; Tumor Necrosis Factor-alpha/metabolism; U937 Cells; Vascular Cell Adhesion Molecule-1/metabolism; Ventricular Function, Left/drug effects; Ventricular Pressure/drug effects

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acrolein / Plant Extracts / Cardiotonic Agents / Myocardial Reperfusion Injury / Cinnamomum aromaticum / Heme Oxygenase (Decyclizing) / Myocardial Infarction / Myocardium Type of study: Clinical_trials Language: En Journal: J Ethnopharmacol Year: 2012 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acrolein / Plant Extracts / Cardiotonic Agents / Myocardial Reperfusion Injury / Cinnamomum aromaticum / Heme Oxygenase (Decyclizing) / Myocardial Infarction / Myocardium Type of study: Clinical_trials Language: En Journal: J Ethnopharmacol Year: 2012 Document type: Article