Metallothionein-dependent up-regulation of TGF-ß2 participates in the remodelling of the myxomatous mitral valve.

Hulin, Alexia; Deroanne, Christophe F; Lambert, Charles A; Dumont, Bruno; Castronovo, Vincent; Defraigne, Jean-Olivier; Nusgens, Betty V; Radermecker, Marc A; Colige, Alain C

Hulin, Alexia; Deroanne, Christophe F; Lambert, Charles A; Dumont, Bruno; Castronovo, Vincent; Defraigne, Jean-Olivier; Nusgens, Betty V; Radermecker, Marc A; Colige, Alain C.

Affiliation

Hulin A; Laboratory of Connective Tissues Biology, GIGA-Cancer, University of Liège, Tour de Pathologie, B23/3, B-4000 Sart-Tilman, Belgium. ahulin@ulg.ac.be

Cardiovasc Res ; 93(3): 480-9, 2012 Mar 01.

Article in En | MEDLINE | ID: mdl-22180604

Subject(s)

Metallothionein/metabolism; Mitral Valve Insufficiency/metabolism; Mitral Valve/metabolism; Transforming Growth Factor beta2/metabolism; Ventricular Remodeling/physiology; ADAM Proteins/genetics; ADAM Proteins/metabolism; ADAMTS1 Protein; Adult; Aged; Cells, Cultured; Female; Humans; Male; Metallothionein/genetics; Microarray Analysis; Middle Aged; Mitral Valve Insufficiency/physiopathology; Transforming Growth Factor beta1/genetics; Transforming Growth Factor beta1/metabolism; Transforming Growth Factor beta2/genetics; Up-Regulation/physiology; Versicans/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ventricular Remodeling / Transforming Growth Factor beta2 / Metallothionein / Mitral Valve / Mitral Valve Insufficiency Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cardiovasc Res Year: 2012 Document type: Article Affiliation country: Belgium Country of publication: United kingdom

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