Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models.

Jones, Nigel C; Nguyen, Thanh; Corcoran, Niall M; Velakoulis, Dennis; Chen, Tracy; Grundy, Robert; O'Brien, Terence J; Hovens, Christopher M

Jones, Nigel C; Nguyen, Thanh; Corcoran, Niall M; Velakoulis, Dennis; Chen, Tracy; Grundy, Robert; O'Brien, Terence J; Hovens, Christopher M.

Affiliation

Jones NC; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.

Neurobiol Dis ; 45(3): 897-901, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22182692

Subject(s)

Antioxidants/therapeutic use; Seizures/drug therapy; Selenium Compounds/therapeutic use; tau Proteins/metabolism; Amygdala/drug effects; Amygdala/metabolism; Analysis of Variance; Animals; Cell Line, Tumor; Convulsants/adverse effects; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation/adverse effects; Enzyme Inhibitors/pharmacology; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Humans; Leucine/genetics; Male; Mutation/genetics; Neuroblastoma; Okadaic Acid/pharmacology; Pentylenetetrazole/adverse effects; Phosphorylation/drug effects; Proline/genetics; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures/etiology; Selenic Acid; Time Factors; Transfection; tau Proteins/genetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Tau Proteins / Selenium Compounds / Antioxidants Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2012 Document type: Article Affiliation country: Australia Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google