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Steroidal C-21 heteroaryl thioethers (Part 2): discovery of orally bioavailable selective glucocorticoid receptor modulators (dissociated steroids).
Biju, Purakkattle; McCormick, Kevin; Aslanian, Robert; Berlin, Michael; Solomon, Daniel; Wang, Hongwu; Lee, Yoon Joo; Bitar, Rema; Prelusky, Daniel; McLeod, Robbie; Jia, Yanlin; Fernandez, Xiomora; Eckel, Stephen; House, Aileen; Lieber, Gissela; Jimenez, Johanna; Kelly, George; Chapman, Richard; Phillips, Jonathan; Anthes, John.
Affiliation
  • Biju P; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. purakkattle.biju@merck.com
Bioorg Med Chem Lett ; 22(2): 1086-90, 2012 Jan 15.
Article in En | MEDLINE | ID: mdl-22197391
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfides / Receptors, Glucocorticoid / Anti-Inflammatory Agents, Non-Steroidal / Drug Discovery Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfides / Receptors, Glucocorticoid / Anti-Inflammatory Agents, Non-Steroidal / Drug Discovery Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: United States