[Gastric MALT lymphoma: anatomo-clinical data and outcome of early stage H. pylori-associated gastric MALT-lymphoma resistant to treatment]. / Lymphome du MALT gastrique : Particularités anatomo-cliniques et évolutives des formes résistantes au traitement.
Tunis Med
; 89(12): 910-5, 2011 Dec.
Article
in Fr
| MEDLINE
| ID: mdl-22198892
ABSTRACT
AIM:
To describe the clinical, endoscopic and histological particularities of early stage HP associated gastric MALT lymphoma resistant to anti Hp treatment and identify predicting factors of resistance.METHODS:
We retrospectively studied 12 patients with primary low grade gastric localized MALT lymphoma treated with anti HP treatment and diagnosed at La Rabta Hospital from 1999 to 2009.RESULTS:
The ultrasonography was normal in 5 patients between the 6 responding patients. Perigastric lymph nodes were found in non responders (33.3%). Hp eradication was achieved in 66% of patients not responding while Hp was eradicated in 100% of responders. The two non-responding patients with failure of eradication of Hp had a strain resistant to Clarithromycin Hp.CONCLUSION:
Predicting factors of failure of anti HP HP resistance to antibiotics, the proximal head, and the presence of perigastric lymph nodes. Recently, chromosomal aberrations and immune-histochemical markers have been implicated as factors of non response to anti Hp.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Drug Resistance, Microbial
/
Helicobacter pylori
/
Helicobacter Infections
/
Lymphoma, B-Cell, Marginal Zone
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
Fr
Journal:
Tunis Med
Year:
2011
Document type:
Article
Affiliation country:
Tunisia