Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects.

Yi, Taolin; Elson, Paul; Mitsuhashi, Masato; Jacobs, Barbara; Hollovary, Emese; Budd, Thomas G; Spiro, Timothy; Triozzi, Pierre; Borden, Ernest C

Yi, Taolin; Elson, Paul; Mitsuhashi, Masato; Jacobs, Barbara; Hollovary, Emese; Budd, Thomas G; Spiro, Timothy; Triozzi, Pierre; Borden, Ernest C.

Affiliation

Yi T; Taussig Cancer Institute, The Cleveland Clinic, Cleveland, OH, USA.

Oncotarget ; 2(12): 1155-64, 2011 Dec.

Article in En | MEDLINE | ID: mdl-22201704

Subject(s)

Antimony Sodium Gluconate; Drug Therapy, Combination/adverse effects; Drug Therapy, Combination/methods; Interferon-alpha/therapeutic use; Adult; Aged; Antimony Sodium Gluconate/administration & dosage; Antimony Sodium Gluconate/adverse effects; Antimony Sodium Gluconate/pharmacokinetics; Antimony Sodium Gluconate/therapeutic use; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Breast Neoplasms/drug therapy; Cisplatin/pharmacology; Colorectal Neoplasms/drug therapy; Dacarbazine/pharmacology; Enzyme Inhibitors/therapeutic use; Female; Gastrointestinal Stromal Tumors/drug therapy; Humans; Interferon alpha-2; Interferon-alpha/administration & dosage; Male; Melanoma/drug therapy; Middle Aged; Phosphoric Monoester Hydrolases/antagonists & inhibitors; Phosphoric Monoester Hydrolases/blood; Protein Tyrosine Phosphatase, Non-Receptor Type 6/antagonists & inhibitors; Recombinant Proteins/administration & dosage; Recombinant Proteins/therapeutic use; Sarcoma/drug therapy; Vinblastine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon-alpha / Antimony Sodium Gluconate / Drug Therapy, Combination Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Oncotarget Year: 2011 Document type: Article Affiliation country: United States

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