Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients.

Troke, Philip J F; Lewis, Marilyn; Simpson, Paul; Gore, Katrina; Hammond, Jennifer; Craig, Charles; Westby, Mike

Troke, Philip J F; Lewis, Marilyn; Simpson, Paul; Gore, Katrina; Hammond, Jennifer; Craig, Charles; Westby, Mike.

Affiliation

Troke PJ; Pfizer Global Research, Sandwich, Kent, United Kingdom.

Antimicrob Agents Chemother ; 56(3): 1331-41, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22203605

Subject(s)

Antiviral Agents/administration & dosage; Drug Resistance, Viral/genetics; Hepacivirus/drug effects; Hepatitis C, Chronic/drug therapy; Pyrones/administration & dosage; Triazoles/administration & dosage; Viral Nonstructural Proteins/genetics; Base Sequence; Cell Line, Tumor; Cloning, Molecular; Drug Resistance, Viral/drug effects; Hepacivirus/physiology; Hepatitis C, Chronic/virology; Humans; Inhibitory Concentration 50; Methionine/genetics; Methionine/metabolism; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; RNA-Dependent RNA Polymerase/antagonists & inhibitors; RNA-Dependent RNA Polymerase/genetics; RNA-Dependent RNA Polymerase/metabolism; Replicon/genetics; Transfection; Viral Nonstructural Proteins/antagonists & inhibitors; Viral Nonstructural Proteins/metabolism; Virus Replication/drug effects; Virus Replication/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyrones / Triazoles / Viral Nonstructural Proteins / Hepacivirus / Hepatitis C, Chronic / Drug Resistance, Viral Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: United States

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