Annexin A1: novel roles in skeletal muscle biology.
J Cell Physiol
; 227(8): 3007-15, 2012 Aug.
Article
in En
| MEDLINE
| ID: mdl-22213240
ABSTRACT
Annexin A1 (ANXA1, lipocortin-1) is the first characterized member of the annexin superfamily of proteins, so called since their main property is to bind (i.e., to annex) to cellular membranes in a Ca(2+) -dependent manner. ANXA1 has been involved in a broad range of molecular and cellular processes, including anti-inflammatory signalling, kinase activities in signal transduction, maintenance of cytoskeleton and extracellular matrix integrity, tissue growth, apoptosis, and differentiation. New insights show that endogenous ANXA1 positively modulates myoblast cell differentiation by promoting migration of satellite cells and, consequently, skeletal muscle differentiation. This suggests that ANXA1 may contribute to the regeneration of skeletal muscle tissue and may have therapeutic implications with respect to the development of ANXA1 mimetics.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Regeneration
/
Annexin A1
/
Muscle, Skeletal
Limits:
Animals
/
Humans
Language:
En
Journal:
J Cell Physiol
Year:
2012
Document type:
Article
Affiliation country:
Italy