Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure.

Nabeshi, Hiromi; Yoshikawa, Tomoaki; Matsuyama, Keigo; Nakazato, Yasutaro; Arimori, Akihiro; Isobe, Masaaki; Tochigi, Saeko; Kondoh, Sayuri; Hirai, Toshiro; Akase, Takanori; Yamashita, Takuya; Yamashita, Kohei; Yoshida, Tokuyuki; Nagano, Kazuya; Abe, Yasuhiro; Yoshioka, Yasuo; Kamada, Haruhiko; Imazawa, Takayoshi; Itoh, Norio; Kondoh, Masuo; Yagi, Kiyohito; Mayumi, Tadanori; Tsunoda, Shin-ichi; Tsutsumi, Yasuo

Nabeshi, Hiromi; Yoshikawa, Tomoaki; Matsuyama, Keigo; Nakazato, Yasutaro; Arimori, Akihiro; Isobe, Masaaki; Tochigi, Saeko; Kondoh, Sayuri; Hirai, Toshiro; Akase, Takanori; Yamashita, Takuya; Yamashita, Kohei; Yoshida, Tokuyuki; Nagano, Kazuya; Abe, Yasuhiro; Yoshioka, Yasuo; Kamada, Haruhiko; Imazawa, Takayoshi; Itoh, Norio; Kondoh, Masuo; Yagi, Kiyohito; Mayumi, Tadanori; Tsunoda, Shin-ichi; Tsutsumi, Yasuo.

Affiliation

Nabeshi H; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.

Nanotechnology ; 23(4): 045101, 2012 Feb 03.

Article in En | MEDLINE | ID: mdl-22214761

Subject(s)

Blood Coagulation/drug effects; Nanoparticles/administration & dosage; Nanoparticles/toxicity; Silicon Dioxide/administration & dosage; Silicon Dioxide/toxicity; Animals; Factor XII/metabolism; Female; Liver/drug effects; Liver/pathology; Mice; Mice, Inbred BALB C; Particle Size; Silicon Dioxide/chemistry; Spleen/drug effects; Spleen/pathology; Survival Analysis; Whole Blood Coagulation Time

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Coagulation / Silicon Dioxide / Nanoparticles Limits: Animals Language: En Journal: Nanotechnology Year: 2012 Document type: Article Affiliation country: Japan

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