Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability.

Bali, Ustav; Barba, Oscar; Dawson, Graham; Gattrell, William T; Horswill, James G; Pan, David A; Procter, Martin J; Rasamison, Chrystelle M; Sambrook Smith, Colin P; Taylor-Warne, Amanda; Wong-Kai-In, Philippe

Bali, Ustav; Barba, Oscar; Dawson, Graham; Gattrell, William T; Horswill, James G; Pan, David A; Procter, Martin J; Rasamison, Chrystelle M; Sambrook Smith, Colin P; Taylor-Warne, Amanda; Wong-Kai-In, Philippe.

Affiliation

Bali U; Prosidion Ltd, Windrush Court, Watlington Road, Oxford, OX4 6LT, United Kingdom.

Bioorg Med Chem Lett ; 22(2): 824-8, 2012 Jan 15.

Article in En | MEDLINE | ID: mdl-22217874

Subject(s)

Diacylglycerol O-Acyltransferase/antagonists & inhibitors; Drug Design; Enzyme Inhibitors/pharmacology; Caco-2 Cells; Diacylglycerol O-Acyltransferase/metabolism; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Humans; Molecular Structure; Permeability/drug effects; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Enzyme Inhibitors / Diacylglycerol O-Acyltransferase Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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