Altered nuclear cofactor switching in retinoic-resistant variants of the PML-RAR&#945; oncoprotein of acute promyelocytic leukemia.

Farris, Mindy; Lague, Astrid; Manuelyan, Zara; Statnekov, Jacob; Francklyn, Christopher

Altered nuclear cofactor switching in retinoic-resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemia.

Farris, Mindy; Lague, Astrid; Manuelyan, Zara; Statnekov, Jacob; Francklyn, Christopher.

Affiliation

Farris M; Department of Microbiology and Molecular Genetics, University of Vermont, Health Sciences Complex, Burlington, Vermont 05405, USA.

Proteins ; 80(4): 1095-109, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22228505

Subject(s)

Leukemia, Promyelocytic, Acute/drug therapy; Oncogene Proteins, Fusion/chemistry; Receptors, Retinoic Acid/chemistry; Amino Acid Sequence; Antineoplastic Agents/pharmacology; Cell Differentiation; Cell Nucleus/chemistry; Chemistry Techniques, Synthetic; Circular Dichroism; Drug Resistance, Neoplasm; Fluorescence Polarization/methods; Humans; Leukemia, Promyelocytic, Acute/pathology; Molecular Sequence Data; Mutation; Myeloid Cells/chemistry; Proteolysis; Retinoic Acid Receptor alpha; Retinol-Binding Proteins/chemistry; Structure-Activity Relationship; Translocation, Genetic; Tretinoin/chemistry; Tretinoin/pharmacology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Promyelocytic, Acute / Oncogene Proteins, Fusion / Receptors, Retinoic Acid Limits: Humans Language: En Journal: Proteins Journal subject: BIOQUIMICA Year: 2012 Document type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google