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Pyridyl-2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists: synthesis, pharmacokinetics, and in vivo potency.
Borthwick, Alan D; Liddle, John; Davies, Dave E; Exall, Anne M; Hamlett, Christopher; Hickey, Deirdre M; Mason, Andrew M; Smith, Ian E D; Nerozzi, Fabrizio; Peace, Simon; Pollard, Derek; Sollis, Steve L; Allen, Michael J; Woollard, Patrick M; Pullen, Mark A; Westfall, Timothy D; Stanislaus, Dinesh J.
Affiliation
  • Borthwick AD; Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK. alan.d.borthwick@drugmoldesign.com
J Med Chem ; 55(2): 783-96, 2012 Jan 26.
Article in En | MEDLINE | ID: mdl-22239250
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxytocin / Morpholines / Receptors, Oxytocin / Diketopiperazines Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxytocin / Morpholines / Receptors, Oxytocin / Diketopiperazines Limits: Animals / Female / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: United kingdom