Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.

Jester, Benjamin W; Gaj, Alicia; Shomin, Carolyn D; Cox, Kurt J; Ghosh, Indraneel

Jester, Benjamin W; Gaj, Alicia; Shomin, Carolyn D; Cox, Kurt J; Ghosh, Indraneel.

Affiliation

Jester BW; Department of Chemistry and Biochemistry, University of Arizona, 1306 East University Boulevard, Tucson, Arizona 85721, United States.

J Med Chem ; 55(4): 1526-37, 2012 Feb 23.

Article in En | MEDLINE | ID: mdl-22257127

Subject(s)

Luciferases/genetics; Protein Kinase Inhibitors/pharmacology; Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/genetics; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/metabolism; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors; Cyclic GMP-Dependent Protein Kinases/genetics; Cyclic GMP-Dependent Protein Kinases/metabolism; Databases, Factual; Genes, Reporter; Protein Kinase C/antagonists & inhibitors; Protein Kinase C/genetics; Protein Kinase C/metabolism; Protein Kinase Inhibitors/chemistry; Rabbits; Recombinant Fusion Proteins/antagonists & inhibitors; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase Inhibitors / Luciferases Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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