Steatorrhoea in cirrhosis: effect of ursodeoxycholic acid administration.
J Int Med Res
; 18(4): 289-97, 1990.
Article
in En
| MEDLINE
| ID: mdl-2227076
ABSTRACT
In a double-blind, crossover study, 10 cirrhotic patients (Child B rating) with steatorrhoea (daily output of faecal fat greater than 8 g) and dyspepsia were placed on a controlled diet for 14 days. Patients then received 150 mg ursodeoxycholic acid (UDCA) or placebo twice daily for 14 days. Faecal fat excretion was reduced from 14.7 to 10.6 g/day by UDCA and dyspepsia symptom scores were also reduced. Serum aspartate aminotransferase concentrations declined significantly (P less than 0.02) following UDCA treatment, whereas serum bile acid levels increased from 35 to 40.5 microM and the percentage of UDCA increased to 22%. It is concluded that UDCA may be useful for many of the symptoms present in patients with liver cirrhosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ursodeoxycholic Acid
/
Celiac Disease
/
Liver Cirrhosis
Type of study:
Clinical_trials
/
Etiology_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Int Med Res
Year:
1990
Document type:
Article
Affiliation country:
Italy