Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-&#954;B signaling after experimental traumatic brain injury.

Chen, Chien-Cheng; Hung, Tai-Ho; Wang, Yen-Ho; Lin, Chii-Wann; Wang, Pei-Yi; Lee, Chun-Yen; Chen, Szu-Fu

Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury.

Chen, Chien-Cheng; Hung, Tai-Ho; Wang, Yen-Ho; Lin, Chii-Wann; Wang, Pei-Yi; Lee, Chun-Yen; Chen, Szu-Fu.

Affiliation

Chen CC; Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China.

PLoS One ; 7(1): e30294, 2012.

Article in En | MEDLINE | ID: mdl-22272328

Subject(s)

Brain Injuries/drug therapy; Flavanones/pharmacology; NF-kappa B/metabolism; Signal Transduction/drug effects; Toll-Like Receptor 4/metabolism; Animals; Apoptosis/drug effects; Blood-Brain Barrier/drug effects; Blood-Brain Barrier/physiopathology; Blotting, Western; Brain Edema/prevention & control; Brain Injuries/metabolism; Brain Injuries/physiopathology; Chemokine CXCL2/genetics; Chemokine CXCL2/metabolism; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Drugs, Chinese Herbal/pharmacology; Enzyme-Linked Immunosorbent Assay; Gene Expression/drug effects; In Situ Nick-End Labeling; Interleukin-1beta/genetics; Interleukin-1beta/metabolism; Interleukin-6/genetics; Interleukin-6/metabolism; Male; Mice; Mice, Inbred C57BL; Permeability/drug effects; Phytotherapy; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Injuries / Signal Transduction / NF-kappa B / Flavanones / Toll-Like Receptor 4 Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: China Country of publication: United States

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