Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy.
Eur J Histochem
; 55(4): e38, 2011 Oct 24.
Article
in En
| MEDLINE
| ID: mdl-22297444
ABSTRACT
Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal Hsp60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat shock protein/molecular chaperones Hsp10, Hsp70, and Hsp90. We found that the levels of these proteins are increased in UC patients at the time of diagnosis and decrease after therapy, supporting the notion that these proteins deserve attention in the study of the mechanisms that promote the development and maintenance of IBD, and as biomarkers of this disease (e.g., to monitor response to treatment at the histological level).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Colitis, Ulcerative
/
Anti-Inflammatory Agents, Non-Steroidal
/
HSP90 Heat-Shock Proteins
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HSP70 Heat-Shock Proteins
/
Chaperonin 10
/
Mesalamine
Limits:
Humans
Language:
En
Journal:
Eur J Histochem
Journal subject:
HISTOCITOQUIMICA
Year:
2011
Document type:
Article
Affiliation country:
Italy