Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.

Shahi, Payam; Park, Dongsu; Pond, Adam C; Seethammagari, Mamatha; Chiou, Shin-Heng; Cho, Kyucheol; Carstens, Julienne L; Decker, William K; McCrea, Pierre D; Ittmann, Michael M; Rosen, Jeffrey M; Spencer, David M

Shahi, Payam; Park, Dongsu; Pond, Adam C; Seethammagari, Mamatha; Chiou, Shin-Heng; Cho, Kyucheol; Carstens, Julienne L; Decker, William K; McCrea, Pierre D; Ittmann, Michael M; Rosen, Jeffrey M; Spencer, David M.

Affiliation

Shahi P; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America.

PLoS One ; 7(1): e30814, 2012.

Article in En | MEDLINE | ID: mdl-22303459

Subject(s)

Homeostasis; Low Density Lipoprotein Receptor-Related Protein-5/metabolism; Protein Multimerization; Wnt Signaling Pathway; Adaptor Proteins, Signal Transducing/metabolism; Amino Acid Sequence; Animals; Axin Protein/metabolism; Casein Kinase I/metabolism; Dishevelled Proteins; Epithelial Cells/cytology; Epithelial Cells/metabolism; Female; Humans; Intracellular Space/metabolism; Male; Mammary Neoplasms, Animal/pathology; Membrane Microdomains/metabolism; Mice; Molecular Sequence Data; Phosphoproteins/metabolism; Phosphorylation; Prostate/pathology; Prostate/transplantation; Protein Binding; Protein Transport; Stromal Cells/metabolism; Stromal Cells/pathology; Structure-Activity Relationship; Tumor Suppressor Proteins/metabolism; beta Catenin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Multimerization / Low Density Lipoprotein Receptor-Related Protein-5 / Wnt Signaling Pathway / Homeostasis Limits: Animals / Female / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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