PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer.

Dulos, John; Carven, Gregory J; van Boxtel, Susan J; Evers, Sabine; Driessen-Engels, Lilian J A; Hobo, Willemijn; Gorecka, Monika A; de Haan, Anton F J; Mulders, Peter; Punt, Cornelis J A; Jacobs, Joannes F M; Schalken, Jack A; Oosterwijk, Egbert; van Eenennaam, Hans; Boots, Annemieke M

Dulos, John; Carven, Gregory J; van Boxtel, Susan J; Evers, Sabine; Driessen-Engels, Lilian J A; Hobo, Willemijn; Gorecka, Monika A; de Haan, Anton F J; Mulders, Peter; Punt, Cornelis J A; Jacobs, Joannes F M; Schalken, Jack A; Oosterwijk, Egbert; van Eenennaam, Hans; Boots, Annemieke M.

Affiliation

Dulos J; Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands. j.dulos@live.com

J Immunother ; 35(2): 169-78, 2012.

Article in En | MEDLINE | ID: mdl-22306905

Subject(s)

Biomarkers, Tumor/immunology; Cytokines/immunology; Melanoma/immunology; Programmed Cell Death 1 Receptor/antagonists & inhibitors; Prostatic Neoplasms/immunology; Antibodies, Blocking/immunology; Antibodies, Blocking/pharmacology; Biomarkers, Tumor/blood; Cell Separation; Cytokines/blood; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Male; Th1 Cells/immunology; Th1 Cells/metabolism; Th17 Cells/immunology; Th17 Cells/metabolism; Th2 Cells/immunology; Th2 Cells/metabolism; Tumor Escape/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Biomarkers, Tumor / Cytokines / Programmed Cell Death 1 Receptor / Melanoma Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: J Immunother Journal subject: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Year: 2012 Document type: Article Affiliation country: Netherlands Country of publication: United States

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