Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood.

Tachibana, Kaori; Hashimoto, Toshikazu; Kato, Rui; Uchida, Yosuke; Ito, Ryoko; Takita, Koichi; Morimoto, Yuji

Tachibana, Kaori; Hashimoto, Toshikazu; Kato, Rui; Uchida, Yosuke; Ito, Ryoko; Takita, Koichi; Morimoto, Yuji.

Affiliation

Tachibana K; Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. shibak@med.hokudai.ac.jp

Paediatr Anaesth ; 22(7): 713-9, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22309594

Subject(s)

Adrenergic alpha-Agonists/pharmacology; Dexmedetomidine/pharmacology; Hippocampus/drug effects; Neuronal Plasticity/drug effects; Synapses/drug effects; Animals; Animals, Newborn; Blood Gas Analysis; CA1 Region, Hippocampal/cytology; CA1 Region, Hippocampal/drug effects; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Evoked Potentials/drug effects; Long-Term Potentiation/drug effects; Male; Membrane Potentials; Pyramidal Cells/drug effects; Rats; Rats, Wistar; Synaptic Transmission/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Adrenergic alpha-Agonists / Dexmedetomidine / Hippocampus / Neuronal Plasticity Limits: Animals Language: En Journal: Paediatr Anaesth Journal subject: ANESTESIOLOGIA / PEDIATRIA Year: 2012 Document type: Article Affiliation country: Japan Country of publication: France

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