Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices.

Dubbelman, A C; Rosing, H; Thijssen, B; Gebretensae, A; Lucas, L; Chen, H; Shumaker, R; Schellens, J H M; Beijnen, J H

Dubbelman, A C; Rosing, H; Thijssen, B; Gebretensae, A; Lucas, L; Chen, H; Shumaker, R; Schellens, J H M; Beijnen, J H.

Affiliation

Dubbelman AC; Department of Clinical Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. anne-charlotte.dubbelman@slz.nl

J Chromatogr B Analyt Technol Biomed Life Sci ; 887-888: 25-34, 2012 Mar 01.

Article in En | MEDLINE | ID: mdl-22309776

Subject(s)

Chromatography, High Pressure Liquid/methods; Phenylurea Compounds/analysis; Quinolines/analysis; Tandem Mass Spectrometry/methods; Drug Stability; Feces/chemistry; Humans; Linear Models; Phenylurea Compounds/blood; Phenylurea Compounds/metabolism; Phenylurea Compounds/urine; Quinolines/blood; Quinolines/metabolism; Quinolines/urine; Reproducibility of Results; Sensitivity and Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Quinolines / Chromatography, High Pressure Liquid / Tandem Mass Spectrometry Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: J Chromatogr B Analyt Technol Biomed Life Sci Journal subject: ENGENHARIA BIOMEDICA Year: 2012 Document type: Article Affiliation country: Netherlands Country of publication: Netherlands

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