Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-Ä¸B signaling, and synergizes with an ERK inhibitor.

Yang, Fan; Jove, Veronica; Chang, Shirley; Hedvat, Michael; Liu, Lucy; Buettner, Ralf; Tian, Yan; Scuto, Anna; Wen, Wei; Yip, M L Richard; Van Meter, Timothy; Yen, Yun; Jove, Richard

Yang, Fan; Jove, Veronica; Chang, Shirley; Hedvat, Michael; Liu, Lucy; Buettner, Ralf; Tian, Yan; Scuto, Anna; Wen, Wei; Yip, M L Richard; Van Meter, Timothy; Yen, Yun; Jove, Richard.

Affiliation

Yang F; Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

Cancer Biol Ther ; 13(6): 349-57, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22313636

Subject(s)

Antineoplastic Agents/pharmacology; Boronic Acids/pharmacology; Cerebellar Neoplasms/drug therapy; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors; Medulloblastoma/drug therapy; NF-kappa B/metabolism; Niacinamide/analogs & derivatives; Phenylurea Compounds/pharmacology; Proto-Oncogene Proteins c-akt/metabolism; Pyrazines/pharmacology; Amino Acid Chloromethyl Ketones/pharmacology; Apoptosis/drug effects; Bortezomib; Caspase 3/metabolism; Caspase 9/metabolism; Cerebellar Neoplasms/metabolism; Cerebellar Neoplasms/pathology; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Cyclin-Dependent Kinase Inhibitor p27/metabolism; Cytochromes c/metabolism; Drug Synergism; Humans; Medulloblastoma/metabolism; Medulloblastoma/pathology; Niacinamide/pharmacology; Protein Kinase Inhibitors/pharmacology; Sorafenib; Tumor Cells, Cultured; bcl-2 Homologous Antagonist-Killer Protein/metabolism; bcl-Associated Death Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Pyrazines / Boronic Acids / Cerebellar Neoplasms / NF-kappa B / Niacinamide / Extracellular Signal-Regulated MAP Kinases / Proto-Oncogene Proteins c-akt / Medulloblastoma / Antineoplastic Agents Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Cancer Biol Ther Journal subject: NEOPLASIAS / TERAPEUTICA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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