A trans-specific polymorphism in ZC3HAV1 is maintained by long-standing balancing selection and may confer susceptibility to multiple sclerosis.

Cagliani, R; Guerini, F R; Fumagalli, M; Riva, S; Agliardi, C; Galimberti, D; Pozzoli, U; Goris, A; Dubois, B; Fenoglio, C; Forni, D; Sanna, S; Zara, I; Pitzalis, M; Zoledziewska, M; Cucca, F; Marini, F; Comi, G P; Scarpini, E; Bresolin, N; Clerici, M; Sironi, M

Cagliani, R; Guerini, F R; Fumagalli, M; Riva, S; Agliardi, C; Galimberti, D; Pozzoli, U; Goris, A; Dubois, B; Fenoglio, C; Forni, D; Sanna, S; Zara, I; Pitzalis, M; Zoledziewska, M; Cucca, F; Marini, F; Comi, G P; Scarpini, E; Bresolin, N; Clerici, M; Sironi, M.

Affiliation

Cagliani R; Scientific Institute IRCCS E. Medea, Bosisio Parini, Lecco, Italy.

Mol Biol Evol ; 29(6): 1599-613, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22319148

Subject(s)

Genetic Predisposition to Disease; Multiple Sclerosis/genetics; Polymorphism, Single Nucleotide; RNA-Binding Proteins/genetics; Selection, Genetic; Acebutolol; Animals; Case-Control Studies; Gene-Environment Interaction; Genetic Association Studies; Genome, Human; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic; Odds Ratio; Pan troglodytes/genetics; Phylogeny; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Structure, Tertiary; RNA-Binding Proteins/chemistry; Sequence Analysis, DNA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selection, Genetic / RNA-Binding Proteins / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Multiple Sclerosis Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Mol Biol Evol Journal subject: BIOLOGIA MOLECULAR Year: 2012 Document type: Article Affiliation country: Italy Country of publication: United States

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